Crystal structure of an engineered, HIV-specific recombinase for removal of integrated proviral DNA
نویسندگان
چکیده
منابع مشابه
Crystal structure of an engineered, HIV-specific recombinase for removal of integrated proviral DNA
As part of the HIV infection cycle, viral DNA inserts into the genome of host cells such that the integrated DNA encoding the viral proteins is flanked by long terminal repeat (LTR) regions from the retrovirus. In an effort to develop novel genome editing techniques that safely excise HIV provirus from cells, Tre, an engineered version of Cre recombinase, was designed to target a 34-bp sequence...
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Damaging the Integrated HIV Proviral DNA with TALENs
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2017
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/gkx603